Formaldehyde → HCID 178517243, 화합물
반응식
[CH2:1]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)[C:2]#[CH:3].[CH2:20]=O.[OH:22][C@H:23]1[CH2:28][CH2:27][C@H:26]([CH2:29][NH2:30])[CH2:25][CH2:24]1>>[OH:22][C@H:23]1[CH2:28][CH2:27][C@H:26]([CH2:29][NH:30][CH2:20][C:3]#[C:2][CH2:1][N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[NH:7][C:6]3[CH:16]=[CH:17][CH:18]=[N:19][C:5]2=3)[CH2:25][CH2:24]1참가 물질
4
실험 절차
Prepared analogously to Example lb) from 5,11-dihydro-11-(prop-2-ynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, paraformaldehyde and trans-(4-hydroxy-cyclohexyl)methylamine in a yield of 31% of theory. Colourless crystals, m.p. 183°-184° C. (after recrystallisation from ethyl acetate and methanol).
후처리
- customColourless crystals, m.p. 183°-184° C. (after recrystallisation from ethyl acetate and methanol)