Phosphorus pentachloride → HCID 14878964, 화합물

HRID 1084772노트

반응식

HRID 1084772 반응식
O[CH2:2][C:3]([CH3:21])([CH3:20])[CH2:4][O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:23]>C1(C)C(C)=CC=CC=1>[Cl:23][CH2:2][C:3]([CH3:21])([CH3:20])[CH2:4][O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1

참가 물질

4

반응물 2

HCID 24819Phosphorus pentachlorideHCID 13854275HCID 13854275, 화합물

생성물 1

HCID 14878964HCID 14878964, 화합물

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

0.5 Gram of 6-phenoxy-2-pyridylmethyl 3-hydroxy-2,2-dimethylpropyl ether was dissolved in 20 ml of dry xylene, and 0.73 g of phosphorus pentachloride was added, followed by heating under reflux for 3 hours. Thereafter, the reaction solution was poured into ice water and extracted with xylene. The xylene layer was washed with water, dried and concentrated. The residue was subjected to column chromatography on silica gel (developing solvent, hexane: ethyl acetate=50:1) to obtain 90 mg of desired 6-phenoxy-2-pyridylmethyl 3-chloro-2,2-dimethylpropyl ether [present compound (1)].

후처리

  1. temperatureby heating
  2. temperatureunder reflux for 3 hours
  3. extractionextracted with xylene
  4. washThe xylene layer was washed with water
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1d2204eebf4142e3a09b41ac4241052b
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05006538

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