Acetic Acid → 2'-Bromoacetanilide

2-Bromo-1-acetylaminobenzene was synthesized in the usual manner from 2-bromoaniline. That is, 150 ml of acetonitrile was added to 25.0 g of 2-bromoaniline, then 15.1 ml of glacial acetic acid was added thereto, and the reaction mixture was heated under reflux for 2 hours. After bringing its temperature to room temperature, 300 ml of ethyl acetate was added thereto, and after the resulting mixture was washed with water twice, the solvent was distilled off, and recrystallization of the crude crystals from a hexane/ethyl acetate solvent mixture was carried out, to obtain 23.2 g (yield: 75%) of 2-bromo-1-acetylaminobenzene.

1. temperaturethe reaction mixture was heated
2. temperatureunder reflux for 2 hours
3. customto room temperature
4. washafter the resulting mixture was washed with water twice
5. distillationthe solvent was distilled off
6. customrecrystallization of the crude crystals from a hexane/ethyl acetate solvent mixture

ORD 기록

ord-5591e418656b4c909c222813e8b51adb

출처 데이터셋

uspto-grants-1991_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05006660