2-(Bromomethyl)thiophene → 3-Phenyl-2-(2-thienylmethylthio)-4(3H)-quinazolinone

반응식

[SH:1][C:2]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:20][C:21]1[S:22][CH:23]=[CH:24][CH:25]=1>>[C:12]1([N:11]2[C:10](=[O:18])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]2[S:1][CH2:20][C:21]2[S:22][CH:23]=[CH:24][CH:25]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

반응물 2

HCID 118299782-(Bromomethyl)thiophene

HCID 178515047HCID 178515047, 화합물

생성물 1

HCID 145751573-Phenyl-2-(2-thienylmethylthio)-4(3H)-quinazolinone수율 37.4%

실험 절차

The title compound was prepared in a yield of 37.4%, using 2-mercapto-3-phenyl-4(3H)-quinazolinone in place of 3- isobutyl-2-mercapto-4(3H)-quinazolinone and 2-bromomethylthiophene in place of 2-chloromethylpyridine hydrochloride.

출처 및 근거

ORD 기록: ord-dea8eee5e0fb4f94927724d9239bced9
출처 데이터셋: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05008266

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