Riluzole → 3(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide

HRID 1085126

반응식

HRID 1085126 반응식
[OH:1][CH2:2][CH2:3][N:4]1[C:8]2[CH:9]=[CH:10][C:11]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:12][C:7]=2[S:6][C:5]1=[NH:18].NC1SC2C=C(OC(F)(F)F)C=CC=2N=1.[Br:34]CCO>C(O)C>[BrH:34].[OH:1][CH2:2][CH2:3][N:4]1[C:8]2[CH:9]=[CH:10][C:11]([O:13][C:14]([F:16])([F:15])[F:17])=[CH:12][C:7]=2[S:6][C:5]1=[NH:18]

참가 물질

5

반응물 3

HCID 5070RiluzoleHCID 108982-BromoethanolHCID 30762523-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline

생성물 1

HCID 30762513(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
20 °C

실험 절차

3-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline may be prepared in the following manner: 2-amino-6-trifluoromethoxybenzothiazole (9.4 g) and 2-bromoethanol (10 g) in absolute ethanol (30 cc) are heated for 95 hours to boiling. The mixture is cooled to a temperature in the region of 20° C. The precipitate formed is filtered off and washed with ethyl ether (100 cc). 3-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline hydrobromide (6.4 g), m.p. 219° C., is thereby obtained.

후처리

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washwashed with ethyl ether (100 cc)

출처 및 근거

ORD 기록
ord-93dd34b74fbb4f82beac53e36185ee27
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05008280

연결된 노트

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