Ethanolamine → HCID 20061116, 화합물

HRID 1085295노트

반응식

HRID 1085295 반응식
Cl[C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH3:12].[CH2:13]([CH2:15][NH2:16])[OH:14].C(N(CC)CC)C>C(O)(C)C>[OH:14][CH2:13][CH2:15][NH:16][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH3:12]

참가 물질

5

반응물 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 132969876-Chloro-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 20061116HCID 20061116, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

6-chloro-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione (3.4 g) was suspended in 30 ml of isopropanol, and the suspension was added with 1.26 ml of ethanolamine and 3.8 ml of triethylamine and then the resultant mixture was refluxed for 3 hours. The reaction mixture was allowed to stand overnight at room temperature, and thereafter crystals formed were collected by filtration, washed with water and then recrystallized using a water-ethanol solution (1:1, v/v), thereby 2.9 g of 6-(2-hydroxyethylamino)-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione being obtained.

후처리

  1. customcrystals formed
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customrecrystallized

출처 및 근거

ORD 기록
ord-2186b3e1ff814175b7218f41cd376278
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05008267

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