Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → (-)-(1R,2S)-2-phenylcyclohexyl chloroacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | rel-(1R,2S)-2-Phenylcyclohexanol | HCID 102793 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (-)-(1R,2S)-2-phenylcyclohexyl chloroacetate | HCID 14295383 | — |
반응 단계
In the next step, (±)-trans-2-phenylcyclohexanol is reacted with chloroacetyl chloride at reflux in a basic solvent such as a mixture of methylene chloride and pyridine or, more preferably, 4-dimethylaminopyridine and methylene chloride. The resulting (±)-trans-2-phenylcyclohexyl chloroacetate of the formula ##STR29## can be isolated by conventional means such as extraction followed by distillation of the organic layer.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05008411 |
| 출처 데이터셋 | uspto-grants-1991_04 |
| ORD ID | ord-a3e42356f5aa4e7588e7b4d3943edfe1 |
| 출처 메모 | uspto-grants-1991_04 |