Triethylamine → HCID 14719431, 화합물

HRID 1085375

반응식

HRID 1085375 반응식
[CH2:1]([O:19][CH2:20][CH2:21][CH2:22][OH:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH3:24][S:25](Cl)(=[O:27])=[O:26].C(N(CC)CC)C>ClCCl>[CH3:24][S:25]([O:23][CH2:22][CH2:21][CH2:20][O:19][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])(=[O:27])=[O:26]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 5553033-Octadecyloxypropanol

생성물 1

HCID 14719431HCID 14719431, 화합물수율 98%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In dichloromethane (50 ml) is dissolved 3-(octadecyloxy)propanol (8.0 g). To the solution are added, under ice-cooling, methanesulfonyl chloride (4.18 g) and triethylamine (5.1 ml). The mixture is stirred at room temperature for one hour. The reaction mixture is washed with water and an aqueous solution of sodium hydrogencarbonate, successively, and then dried. The solvent is distilled off under reduced pressure to give the above-titled compound (9.7 g).

후처리

  1. additionTo the solution are added, under ice-
  2. temperaturecooling
  3. washThe reaction mixture is washed with water
  4. dry with materialan aqueous solution of sodium hydrogencarbonate, successively, and then dried
  5. distillationThe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-5231a62ac23d4fbd8898c56889ce6997
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05008454

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