Methylamine → 6-amino-4-methyl-beta-carbolin-3-carboxylic acid N-methylamide

HRID 1085451노트

반응식

HRID 1085451 반응식
C(O[C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[CH:15][C:14]([NH2:20])=[CH:13][CH:12]=3)=[O:5])C.[CH3:21][NH2:22]>C(O)CO>[CH3:21][NH:22][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[CH:15][C:14]([NH2:20])=[CH:13][CH:12]=3)=[O:5]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 130373386-Amino-4-methyl-beta-carboline-3-carboxylic-acid-ethylester

생성물 1

HCID 130373546-amino-4-methyl-beta-carbolin-3-carboxylic acid N-methylamide

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

실험 절차

1.81 g of 6-amino-4-methyl-β-carbolin-3-carboxylic acid ethyl ester is suspended in 15 ml of ethylene glycol and, while cooling with ice, methylamine is introduced until saturation point is reached. The mixture is then stirred at room temperature for 16 hours, stirred into 100 ml of ice water and the product is filtered off, dried and recrystallized from ethanol-chloroform. 1.42 g of 6-amino-4-methyl-β-carbolin-3-carboxylic acid N-methylamide of melting point 281°-285° C. is obtained.

후처리

  1. additionis introduced until saturation point
  2. filtrationthe product is filtered off
  3. customdried
  4. customrecrystallized from ethanol-chloroform

출처 및 근거

ORD 기록
ord-846b39671c6e4e3abe9b8e0cbc61e74c
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05010077

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