Ethanol → HCID 86744734, 화합물

HRID 1085464노트

반응식

HRID 1085464 반응식
[NH:1]([C:3]1[N:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH:10]2[CH2:12][CH2:11]2)[N:4]=1)[NH2:2].C[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O.[CH2:23](O)C>>[CH3:9][C:7]1[CH:6]=[C:5]([CH:10]2[CH2:11][CH2:12]2)[N:4]=[C:3]([NH:1][N:2]=[C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])[CH3:14])[N:8]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 71481-Phenyl-1-propanoneHCID 20060099HCID 20060099, 화합물

생성물 1

HCID 86744734HCID 86744734, 화합물

실험 절차

3.3 g of 2-hydrazino-4-methyl-6-cyclopropylpyrimidine and 2.7 g of 2-methylacetophenone are heated to boiling in 40 ml of ethanol and boiled under reflux for 20 hours with stirring. The reaction solution is then cooled and the solvent is evaporated off in vacuo. For purification, the oily residue is chromatographed using hexane/ethyl acetate (2:1) over a column of silica gel.

후처리

  1. temperatureunder reflux for 20 hours
  2. temperatureThe reaction solution is then cooled
  3. customthe solvent is evaporated off in vacuo
  4. customFor purification
  5. customthe oily residue is chromatographed

출처 및 근거

ORD 기록
ord-47e23cb0af584577b7e81ede76200279
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05010082

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