Ethanolamine → N-(2-hydroxyethyl)-4-thiazolecarboxamide

HRID 1085495노트

반응식

[S:1]1[CH:5]=[C:4]([C:6]([O:8]CC)=O)[N:3]=[CH:2]1.[CH2:11]([CH2:13][NH2:14])[OH:12]>>[OH:12][CH2:11][CH2:13][NH:14][C:6]([C:4]1[N:3]=[CH:2][S:1][CH:5]=1)=[O:8]

참가 물질

반응물 2

HCID 700Ethanolamine

HCID 5003096Ethyl thiazole-4-carboxylate

생성물 1

HCID 20060259N-(2-hydroxyethyl)-4-thiazolecarboxamide

반응 조건

온도: 100 °C

실험 절차

A mixture of ethyl 4-thiazolecarboxylate (24.49 g) and monoethanolamine (28.0 ml) was heated at 100° C. with stirring for 1 hour 20 minutes. After being cooled, the mixture was subjected to column chromatography on silica gel (245 g) and eluted with chloroform. The fractions containing the objective compound were combined and concentrated under reduced pressure to give a light brown oil of N-(2-hydroxyethyl)-4-thiazolecarboxamide (25.93 g).

후처리

temperatureAfter being cooled
washeluted with chloroform
additionThe fractions containing the objective compound
concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록: ord-2464eafe9acc4eecac2f722931d9bdd3
출처 데이터셋: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05010093

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