Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2-Amino-4,6-difluoropyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 2,4,6-Trifluoropyrimidine | HCID 69677 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Amino-4,6-difluoropyrimidine | HCID 1201480 | 54.9% |
반응 단계
This entailed, in the first stage of the synthesis, absolute ethanol being saturated with ammonia at 0° C., and a solution of 2,4,6-trifluoropyrimidine (II) and ethanol then being added to the solution obtained in this way. It was possible, after elaborate separation of the isomers, to isolate 2-amino-4,6-difluoropyrimidine IVa' in 54.9% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05011927 |
| 출처 데이터셋 | uspto-grants-1991_04 |
| ORD ID | ord-9c9f0f8f7cec4a7a99036410dd7420a8 |
| 출처 메모 | uspto-grants-1991_04 |