5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide → Flosequinoxan
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[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O>C(O)(C)C>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1참가 물질
3
실험 절차
A solution of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (1.0 g), prepared in a similar manner to that described in Example 11, in isopropyl alcohol (20 ml) was heated to reflux for 3.5 hours. The mixture was cooled to ambient temperature and the product collected by filtration and dried in vacuo at 50° to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 234.5°-235° (0.6 g).
후처리
- temperaturewas heated
- temperatureto reflux for 3.5 hours
- filtrationthe product collected by filtration
- customdried in vacuo at 50°
출처 및 근거
- ORD 기록
- ord-df2c07268b5c48a69f05553f8fb6dcab
- 출처 데이터셋
- uspto-grants-1991_04
- 특허 번호
- US05011931
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