Triethylamine → Flosequinoxan
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[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O.C(N(CC)CC)C>CCCCCC>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1참가 물질
4
실험 절차
A mixture of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (0.20 g), prepared in a similar manner to that described in Example 11, and triethylamine (20 ml) was stirred at ambient temperature for 2.5 hours. Hexane (30 ml) was added to the mixture. The solid product collected by filtration of the mixture was washed with hexane (2×5 ml) and dried at 50° in vacuo to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 233°-234.5° (0.16 g).
후처리
- customprepared in a similar manner to that
- filtrationThe solid product collected by filtration of the mixture
- washwas washed with hexane (2×5 ml)
- customdried at 50° in vacuo
출처 및 근거
- ORD 기록
- ord-b9cd02beca144f6398ac4b82babe2a90
- 출처 데이터셋
- uspto-grants-1991_04
- 특허 번호
- US05011931
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