반응식
ClC1C=C(C=CC=1)C(OO)=[O:6].[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:23])[CH2:20][S:21][CH3:22])=[C:15]([NH:24][CH3:25])[CH:14]=1>ClCCl>[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:23])[CH2:20][S:21]([CH3:22])=[O:6])=[C:15]([NH:24][CH3:25])[CH:14]=1참가 물질
4
실험 절차
A solution of 3-chloroperoxybenzoic acid (3.49 g) in dichloromethane (80 ml) was added to a stirred solution of 1-(4-fluoro-2-methylaminophenyl)-2(methylthio)ethanone (4.3 g), prepared in a similar manner to that described in Example 2, in dichloromethane (75 ml) under nitrogen over 15 minutes whilst maintaining the temperature below 25°. The mixture was stirred for a further 2 hours at ambient temperature. The solution was washed with saturated aqueous sodium hydrogen carbonate solution (3×50 ml) an evaporated in vacuo to give a solid product. Crystallisation from toluene gave 1-(4-fluoro-2-methylaminophenyl)-2-methylsulphinylethanone, m.p. 137°-138°.
후처리
- customprepared in a similar manner to that
- temperaturewhilst maintaining the temperature below 25°
- washThe solution was washed with saturated aqueous sodium hydrogen carbonate solution (3×50 ml)
- customan evaporated in vacuo
- customto give a solid product
- customCrystallisation from toluene
출처 및 근거
- ORD 기록
- ord-ba83ec0264d54eeaaecb4b86350e3376
- 출처 데이터셋
- uspto-grants-1991_04
- 특허 번호
- US05011931
연결된 노트
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