Ethanol → N'-[1-(Pyridin-2-yl)ethylidene]benzohydrazide

HRID 1085935노트

반응식

HRID 1085935 반응식
[C:1]([NH:9][NH2:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)(=O)[CH3:12].C(O)C>O1CCOCC1>[N:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:11](=[N:10][NH:9][C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:12]

참가 물질

5

반응물 3

HCID 702EthanolHCID 11955BenzoylhydrazineHCID 142862-Acetylpyridine

생성물 1

HCID 1072163N'-[1-(Pyridin-2-yl)ethylidene]benzohydrazide수율 64%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 6.81 gm (0.05 mole) of benzhydrazide, 6.06 gm (0.05 mole) of 2-acetylpyridine and 100 ml of ethanol is stirred at reflux 2 hr. Then sufficient dioxane is added to the boiling mixture to furnish a solution. The hot solution is filtered. The filtrate is diluted to the cloud point with water, cooled to room temperature, and then chilled in the refrigerator. The product is collected and dried to yield 7.61 gm (64%) of the title compound having a melting point of 151.6° C.

후처리

  1. temperatureat reflux 2 hr
  2. customto furnish a solution
  3. filtrationThe hot solution is filtered
  4. additionThe filtrate is diluted to the cloud point with water
  5. temperaturechilled in the refrigerator
  6. customThe product is collected
  7. customdried

출처 및 근거

ORD 기록
ord-2ca308f759b248c3b30333032217cae1
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05011932

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