반응식
[CH3:1][C:2]([NH:5][CH2:6][CH:7]([OH:17])C1C=CC(O)=C(CO)C=1)([CH3:4])[CH3:3].[C:18]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=O)C.BrC[C:29]([O:31][C:32](=[O:40])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[OH:39])=O.CC(NCC1C=CC=CC=1)(C)C>>[CH3:29][O:31][C:32](=[O:40])[C:33]1[CH:38]=[C:37]([C:7](=[O:17])[CH2:6][N:5]([C:2]([CH3:4])([CH3:3])[CH3:1])[CH2:18][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:36]=[CH:35][C:34]=1[OH:39]참가 물질
5
실험 절차
Albuterol has been prepared, see Irish Patent Specification No. 31391, Aug. 9, 1972, starting from the appropriate acetophenone derivative methyl-5-(bromoacetyl-2-hydroxybenzoate, by condensation with N-(1,1-dimethylethyl)benzenemethanamine in the presence of base to form the ketonic ester, methyl-5[[(1,1-dimethylethyl)(phenylmethyl)-amino]acetyl]-2-hydroxybenzoate. The ketonic ester is reduced with lithium aluminum hydride in tetrahydrofuran under nitrogen to yield α1 -[[(1,1-dimethylethyl)-(phenylmethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol which is subsequently debenzylated with hydrogen in the presence of palladium on carbon catalyst to produce albuterol.
출처 및 근거
- ORD 기록
- ord-5b8dcbadf97f4773909981ee451ff8e5
- 출처 데이터셋
- uspto-grants-1991_04
- 특허 번호
- US05011993
연결된 노트
불러오는 중…