Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Metoclopramide sulfide → 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[4-(methylsulfinyl)butoxy]benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Metoclopramide sulfide | HCID 124098 | — |
| 반응물 | 4-Amino-5-chloro-N-[2-(diethylamino]ethyl]-2-[4-(methylthio)butoxy]benzamide | HCID 14372577 | — |
| 생성물 | 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[4-(methylsulfinyl)butoxy]benzamide | HCID 14372578 | 78% |
반응 단계
The general procedure from Example 21 is repeated except that the 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[2-(methylthio)ethoxy]benzamide utilized therein was replaced with the product from Step A to give the title compound in 78% yield after chromatography on silica and crystallization from methylene chloride-ether, as a solid, mp. 80°-83° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05011992 |
| 출처 데이터셋 | uspto-grants-1991_04 |
| ORD ID | ord-3736ffac7be74bff8be8bf8d8d0b9c07 |
| 출처 메모 | uspto-grants-1991_04 |