HCID 178455928, 화합물 → Fmoc-Arg-Ile-OH

HRID 1086125노트

반응식

HRID 1086125 반응식
[NH:1]([C:25]([O:27][CH2:28][CH:29]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]2[C:30]1=[CH:31][CH:32]=[CH:33][CH:34]=2)=[O:26])[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([O:20]C(C)(C)C)=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8]>FC(F)(F)C(O)=O>[NH:1]([C:25]([O:27][CH2:28][CH:29]1[C:30]2[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:36]2[C:41]1=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:26])[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([OH:20])=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

참가 물질

3

반응물 1

HCID 178455928HCID 178455928, 화합물

생성물 1

HCID 178455927Fmoc-Arg-Ile-OH

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

15.8 g of Fmoc-Arg-Ile-OtBu are dissolved in 150 ml of 90% strength aqueous trifluoroacetic acid. The solution is left to stand at room temperature for 1 hour, and is concentrated. The residue is triturated twice with diethyl ether, the ether being decanted off each time. Water is added to the residue, and the pH is adjusted to with saturated NaHCO3 solution. The precipitate is filtered off with suction and dried.

후처리

  1. waitThe solution is left
  2. concentrationis concentrated
  3. customThe residue is triturated twice with diethyl ether
  4. customthe ether being decanted off each time
  5. additionWater is added to the residue
  6. filtrationThe precipitate is filtered off with suction
  7. customdried

출처 및 근거

ORD 기록
ord-7cc252e9a0024683826e317a26012343
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05011825

반응 노트

불러오는 중…