Dicyclohexylcarbodiimide → HCID 178455926, 화합물

HRID 1086127노트

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HRID 1086127 반응식
C1CCC(N=C=NC2CCCCC2)CC1.[NH:16]([C:36]([O:38][CH2:39][CH:40]1[C:52]2[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=2)[C:46]2[C:41]1=[CH:42][CH:43]=[CH:44][CH:45]=2)=[O:37])[C@H:17]([C:25]([NH:27][C@H:28]([C:33](O)=[O:34])[C@H:29]([CH2:31][CH3:32])[CH3:30])=[O:26])[CH2:18][CH2:19][CH2:20][NH:21][C:22](=[NH:24])[NH2:23].[NH2:53][C@H:54]([C:58]([NH:60][C@H:61]([C:69]([NH:71][C@H:72]([C:77]([O:79][CH2:80][C:81]1[CH:86]=[CH:85][CH:84]=[CH:83][CH:82]=1)=[O:78])[C@H:73]([CH2:75][CH3:76])[CH3:74])=[O:70])[CH2:62][CH2:63][CH2:64][NH:65][C:66](=[NH:68])[NH2:67])=[O:59])[CH:55]([CH3:57])[CH3:56].C1C=C2C(N(O)N=NC2=CC=1)=O>CN(C)C=O>[NH:16]([C:36]([O:38][CH2:39][CH:40]1[C:52]2[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=2)[C:46]2[C:41]1=[CH:42][CH:43]=[CH:44][CH:45]=2)=[O:37])[C@H:17]([C:25]([NH:27][C@H:28]([C:33]([NH:53][C@H:54]([C:58]([NH:60][C@H:61]([C:69]([NH:71][C@H:72]([C:77]([O:79][CH2:80][C:81]1[CH:82]=[CH:83][CH:84]=[CH:85][CH:86]=1)=[O:78])[C@H:73]([CH2:75][CH3:76])[CH3:74])=[O:70])[CH2:62][CH2:63][CH2:64][NH:65][C:66](=[NH:67])[NH2:68])=[O:59])[CH:55]([CH3:57])[CH3:56])=[O:34])[C@H:29]([CH2:31][CH3:32])[CH3:30])=[O:26])[CH2:18][CH2:19][CH2:20][NH:21][C:22](=[NH:23])[NH2:24]

참가 물질

6

반응물 4

HCID 10868DicyclohexylcarbodiimideHCID 730263-hydroxy-1,2,3-benzotriazin-4(3H)-oneHCID 178455924HCID 178455924, 화합물HCID 178455927Fmoc-Arg-Ile-OH

생성물 1

HCID 178455926HCID 178455926, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3.3 g of DCC are added, at 0° C., to a stirred solution of 7.4 g (15 mmol) of Fmoc-Arg-Ile-OH, 7.15 g of H-Val-Arg-Ile-OBzl and 2.44 g of HOObt in 150 ml of dimethylformamide. The working-up is carried out in analogy to Example 2b. The dried residue is triturated with ethyl acetate, filtered off with suction and dried.

후처리

  1. customThe dried residue is triturated with ethyl acetate
  2. filtrationfiltered off with suction
  3. customdried

출처 및 근거

ORD 기록
ord-21cd934257bb4d6fb73867de9389b90f
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05011825

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