Morpholine → 4-(6-Bromoimidazo[1,2-a]pyrazin-8-yl)morpholine

HRID 1086169노트

반응식

HRID 1086169 반응식
[Br:1][C:2]1[N:3]=[C:4](Br)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>C(O)C>[Br:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

생성물 1

HCID 100394454-(6-Bromoimidazo[1,2-a]pyrazin-8-yl)morpholine수율 85%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 1 g (3,6 mol) of 6,8-dibromoimidazo[1,2-a]pyrazine and 1 g (11.2 mmol) of morpholine in 15 ml of anhydrous ethanol is brought to reflux for 12 hours. After evaporation of the solvant and chromatography on an alumina column (eluant=CH2Cl2), 0.88 g (Yld=85%) of 6-bromo 8-morpholinoimidazo[1,2-a]pyrazine (m.p. 191° C.) is obtained.

후처리

  1. temperatureto reflux for 12 hours
  2. customAfter evaporation of the solvant and chromatography on an alumina column (eluant=CH2Cl2)

출처 및 근거

ORD 기록
ord-58b7ba91000045c19693a28921fb6cdb
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05028605

반응 노트

불러오는 중…