Methylamine → 5-Bromo-N~3~-methylpyrazine-2,3-diamine

HRID 1086171노트

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HRID 1086171 반응식
[CH3:1][NH2:2].Br[C:4]1[C:5]([NH2:11])=[N:6][CH:7]=[C:8]([Br:10])[N:9]=1>C(O)C>[NH2:11][C:5]1[C:4]([NH:2][CH3:1])=[N:9][C:8]([Br:10])=[CH:7][N:6]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 6200042-Amino-3,5-dibromopyrazine

생성물 1

HCID 121985205-Bromo-N~3~-methylpyrazine-2,3-diamine수율 40%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
130 °C

실험 절차

1.55 g (50 mmol) of 40% strength aqueous methylamine solution is added to a solution of 2.53 g (10 mmol) of 3,5-dibromo-2-aminopyrazine in ethanol. The mixture is stirred in an autoclave at 130° C. for 17 hours. After evaporation of the solvent under reduced pressure, the product is purified by chromatography on a silica column (eluant=CH2Cl2, to which 3% of CH3OH has been added). 0.8 g (Yld=40%) of 2-amino-5-bromo-3-methylaminopyrazine (m.p. 121° C.) is obtained.

후처리

  1. customAfter evaporation of the solvent under reduced pressure
  2. customthe product is purified by chromatography on a silica column (eluant=CH2Cl2, to which 3% of CH3OH has been added)

출처 및 근거

ORD 기록
ord-5b64c1009c9b4dc2b6f3c8e85a128999
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05028605

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