Ethanol → 5-(3-(4-(4-(2-Quinolinylmethyloxy)styryl)phenoxy)propyl)tetrazole

HRID 1086239노트

반응식

HRID 1086239 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:27]=[CH:26][C:16]([CH:17]=[CH:18][C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=2)=[CH:15][CH:14]=1.Cl[CH2:29][CH2:30][CH2:31][C:32]1[NH:36][N:35]=[N:34][N:33]=1.[OH-].[K+].C(O)C>O.CCCCCC.C(OCC)(=O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:27]=[CH:26][C:16]([CH:17]=[CH:18][C:19]2[CH:20]=[CH:21][C:22]([O:25][CH2:29][CH2:30][CH2:31][C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:23][CH:24]=2)=[CH:15][CH:14]=1

참가 물질

7

반응물 4

HCID 702EthanolHCID 14797Potassium HydroxideHCID 539691924-(4-(2-Quinolinylmethyloxy)styryl)phenolHCID 178478461HCID 178478461, 화합물

생성물 1

HCID 1784366615-(3-(4-(4-(2-Quinolinylmethyloxy)styryl)phenoxy)propyl)tetrazole

시약·촉매·용매 2

HCID 962Water용매HCID 21226206Ethyl acetate hexane용매

실험 절차

A mixture of (0.014 mol) 4-(4-(2-quinolinylmethyloxy)-styryl)phenol, (0.14 mol) 5-(3-chloropropyl)tetrazole, 2 g (0.036 mol) KOH in 5 ml water, and 50 ml ethanol is heated over a steam bath for a period of 3 hours. The reaction mixture is concentrated to dryness and slurried into water and extracted with methylene chloride. The methylene chloride extract is washed with water, dried over MgSO4 and concentrated under reduced pressure to obtain solid which is passed through a silica gel column using hexane/ethyl acetate as eluent. Evaporation of eluent gives 5-(3-(4-(4-(2-quinolinylmethyloxy)styryl)phenoxy)propyl)tetrazole.

후처리

  1. temperatureis heated over a steam bath for a period of 3 hours
  2. concentrationThe reaction mixture is concentrated to dryness
  3. extractionextracted with methylene chloride
  4. extractionThe methylene chloride extract
  5. washis washed with water
  6. dry with materialdried over MgSO4
  7. concentrationconcentrated under reduced pressure
  8. customto obtain solid which
  9. customEvaporation of eluent

출처 및 근거

ORD 기록
ord-5195125e6ce24043a7c5a6f94f42acd8
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05028615

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