Ethyl Dodecanoate → 1-(2-Hydroxyethyl)-2-undecylimidazoline

반응식

[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][OH:7].[C:8](OCC)(=O)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>>[OH:7][CH2:6][CH2:5][N:4]1[CH2:3][CH2:2][N:1]=[C:19]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH3:8]

참가 물질

반응물 2

HCID 7800Ethyl Dodecanoate

HCID 8112N-(2-Hydroxyethyl)ethylenediamine

생성물 1

HCID 87091-(2-Hydroxyethyl)-2-undecylimidazoline수율 69.5%

실험 절차

58.7 g (564.4 mmoles) of 2-(2-aminoethylamino)ethanol and 122.8 g (538.6 mmoles) of ethyl dodecanoate were heated at 125° C. and ethanol was removed by distillation. 100 ml of toluene was cautiously added and water was removed azeotropically on further reflux. The reaction mixture was fractionally distilled to give 100.2 g (69.5%) of pure product, m.p. 40°-42° C.

후처리

customethanol was removed by distillation
addition100 ml of toluene was cautiously added
customwater was removed azeotropically on further reflux
distillationThe reaction mixture was fractionally distilled

출처 및 근거

ORD 기록: ord-9a32d83b4e084061b5532e0c93cbc024
출처 데이터셋: uspto-grants-1991_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05030629

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