Water → Methyl [2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetate

HRID 1086519노트

반응식

HRID 1086519 반응식
[ClH:1].[NH2:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:12][C:13]([O:15][CH3:16])=[O:14])[CH:9]=2)[CH2:4]1.C(=O)([O-])[O-].[K+].[K+].O.Cl[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[S:31](Cl)(=[O:33])=[O:32]>C(OCC)(=O)C>[Cl:1][C:29]1[CH:28]=[CH:27][C:26]([S:31]([NH:2][CH:3]2[CH2:11][C:10]3[C:5](=[CH:6][CH:7]=[C:8]([CH2:12][C:13]([O:15][CH3:16])=[O:14])[CH:9]=3)[CH2:4]2)(=[O:33])=[O:32])=[CH:25][CH:30]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 761872-Chlorobenzenesulfonyl chlorideHCID 23359670Methyl (2-aminoindan-5-yl)acetate hydrochloride

생성물 1

HCID 53769737Methyl [2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetate수율 79.5%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of methyl (2-aminoindan-5-yl)acetate hydrochloride (2.43 g), potassium carbonate (5.52 g), water (60 ml), ethyl acetate (60 ml) and 4 chlorophenylsulfonyl chloride (2.11 g) is stirred at room temperature for one hour. The ethyl acetate layer is separated from the reaction mixture, washed with aqueous saline solution, dried, and distilled under reduced pressure to remove the solvent. The resulting crude product is recrystallized from a mixture of ethyl acetate and n-hexane to give methyl [2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetate (3.02 g).

후처리

  1. customThe ethyl acetate layer is separated from the reaction mixture
  2. washwashed with aqueous saline solution
  3. customdried
  4. distillationdistilled under reduced pressure
  5. customto remove the solvent
  6. customThe resulting crude product is recrystallized from a mixture of ethyl acetate and n-hexane

출처 및 근거

ORD 기록
ord-ae444deb1d154f5a945eb9bc984b9fb9
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05030652

반응 노트

불러오는 중…