Water → N-(2,3-Dihydro-1H-inden-2-yl)formamide

HRID 1086524노트

반응식

HRID 1086524 반응식
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:11](O)(=[O:13])C.C(OC=O)=O.O>O1CCCC1>[CH:11]([NH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)=[O:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 763102-AminoindaneHCID 86740153HCID 86740153, 화합물

생성물 1

HCID 14835235N-(2,3-Dihydro-1H-inden-2-yl)formamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 2-aminoindan (19.95 g) in tetrahydrofuran is added an solution of 2M acetic acid-formic acid anhydride in tetrahydrofuran under ice cooling, and the mixture is reacted at room temperature. To the reaction mixture is added water, and then, the solvent is distilled off, and the residue is extracted with ethyl acetate. After distilling off the solvent, the residue is recrystallized from ethyl acetate - n-hexane to give 2-formylaminoindan (19.02 g).

후처리

  1. customthe mixture is reacted at room temperature
  2. distillationthe solvent is distilled off
  3. extractionthe residue is extracted with ethyl acetate
  4. distillationAfter distilling off the solvent
  5. customthe residue is recrystallized from ethyl acetate - n-hexane

출처 및 근거

ORD 기록
ord-c76632c77bc844c5b18d5a07bd9d9b35
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05030652

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