Ammonia → 6-methyl-5H-thiazolo-(2,3-b)-quinazolin-5-one
반응식
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH2:11])[C:7]=1[C:8]([NH2:10])=[O:9].Cl[C:13]1[S:14][CH:15]=[CH:16]N=1.N>O>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:7]=1[C:8](=[O:9])[N:10]1[CH:16]=[CH:15][S:14][C:13]1=[N:11]2참가 물질
5
반응 조건
- 온도
- 140 °C
실험 절차
While stirring, 22.5 g of 6-methylanthranilamide was added to 18 g of 2-chlorothiazole. The reaction mixture was heated over a 20-minute period to 140° C. and stirred for 4 hours. Water was added to the reaction mixture, and a pH of 10 was set by adding 25% strength ammonia solution. Working up in the conventional manner gave 22.3 g (69%) of compound 3; m.p. 148°-150° C.
후처리
- stirringstirred for 4 hours
출처 및 근거
- ORD 기록
- ord-42b06d3991d9403ca7f102aecffac76c
- 출처 데이터셋
- uspto-grants-1991_07
- 특허 번호
- US05030727
반응 노트
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