6-chloro-2-methyl-9-(beta-D-ribofuranosyl)-9H-purine → HCID 178433181, 화합물

HRID 1086803노트

반응식

HRID 1086803 반응식
Cl[C:2]1[N:10]=[C:9]([CH3:11])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:12]1[O:18][C@H:17]([CH2:19][OH:20])[C@@H:15]([OH:16])[C@H:13]1[OH:14].Cl.[NH2:22][C@H:23]1[CH2:28][CH2:27][C@H:26]([OH:29])[CH2:25][CH2:24]1>C(O)(C)C>[OH:29][C@H:26]1[CH2:27][CH2:28][C@H:23]([NH:22][C:2]2[C:3]3[N:4]=[CH:5][N:6]([C:7]=3[N:8]=[C:9]([CH3:11])[N:10]=2)[C@@H:12]2[O:18][C@H:17]([CH2:19][OH:20])[C@@H:15]([OH:16])[C@H:13]2[OH:14])[CH2:24][CH2:25]1

참가 물질

4

반응물 2

HCID 542785016-chloro-2-methyl-9-(beta-D-ribofuranosyl)-9H-purineHCID 178479278HCID 178479278, 화합물

생성물 1

HCID 178433181HCID 178433181, 화합물수율 79.1%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 6-chloro-2-methyl-9-(β-D-ribofuranosyl)-9H-purine (902 mg), trans-4-aminocyclohexanol hydrochloride (1.14 g) and DEA (1.94 g) in isopropanol (50 ml) was heated at reflux with stirring under nitrogen for 17 h. The resulting cooled reaction mixture was adsorbed onto silica (Merck 9385) and purified by column chromatography on silica (Merck 9385) eluting with System B (10:1 then 8:1) to give the title compound (0.9 g) as a solid.

후처리

  1. temperaturewas heated
  2. temperatureat reflux
  3. temperatureThe resulting cooled
  4. customreaction mixture
  5. custompurified by column chromatography on silica (Merck 9385)
  6. washeluting with System B (10:1

출처 및 근거

ORD 기록
ord-eee0310c533c4584987382826d592722
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05032583

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