Dicyclohexylcarbodiimide → HCID 178444548, 화합물

HRID 1086971노트

반응식

HRID 1086971 반응식
[CH3:1][CH:2]([C:5]1[S:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[N:8][N:9]=1)[CH2:3][CH3:4].[CH2:17]([C@H:22]1[CH2:27][CH2:26][C@H:25]([C:28](O)=[O:29])[CH2:24][CH2:23]1)[CH2:18][CH2:19][CH2:20][CH3:21].C1(N=C=NC2CCCCC2)CCCCC1.N1(C2C=CN=CN=2)CCCC1>C(Cl)Cl>[CH3:1][CH:2]([C:5]1[S:6][C:7]([C:10]2[CH:11]=[CH:12][C:13]([O:16][C:28]([C@H:25]3[CH2:26][CH2:27][C@H:22]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:23][CH2:24]3)=[O:29])=[CH:14][CH:15]=2)=[N:8][N:9]=1)[CH2:3][CH3:4]

참가 물질

6

반응물 4

HCID 10868DicyclohexylcarbodiimideHCID 218558524-(1-Pyrrolidinyl)pyrimidineHCID 1357784881-Methylpropyl-5-[4-hydroxyphenyl]-1,3,4-thiadiazoleHCID 178444557HCID 178444557, 화합물

생성물 1

HCID 178444548HCID 178444548, 화합물수율 45.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Into a mixture of 0.3 g (1.28×10-3 mol) of 1-methylpropyl-5-[4-hydroxyphenyl]-1,3,4-thiadiazole, 0.26 g (1.31×10-3 mol) of trans-4-n-pentylcyclohexanecarboxylic acid, 0.27 g (1.31×10-3 mol) of dicyclohexylcarbodiimide and 0.03 g of 4-(1-pyrrolidinyl)pyrimidine, 15 ml of methylene chloride was added, followed by 20 hours of stirring at room temperature. After the reaction, the reaction was filtered and the solid was washed with methylene chloride. The filtrate and the washing liquid were dehydrated, and the solvent was distilled off therefrom to obtain a crude product, which was then recrystallized twice to obtain 0.24 g of 2-(1-methylpropyl)-5-[4-(trans-4-n-pentylcyclohexylcarbonyloxy)-phenyl]-1,3,4-thiadiazole. (Yield: 45.2%).

후처리

  1. additionwas added
  2. customAfter the reaction
  3. filtrationthe reaction was filtered
  4. washthe solid was washed with methylene chloride
  5. distillationthe solvent was distilled off
  6. customto obtain a crude product, which
  7. customwas then recrystallized twice

출처 및 근거

ORD 기록
ord-1f6ca3367e6c4a789589b764dd7ea3f3
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05034151

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