Methylamine → N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide

HRID 1087071노트

반응식

HRID 1087071 반응식
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8](OCC)=[O:9])[C:3]1=[O:13].[CH3:14][NH2:15]>O>[CH3:14][NH:15][C:8](=[O:9])[CH2:7][N:4]1[CH2:5][CH2:6][CH:2]([OH:1])[C:3]1=[O:13]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 13385945ethyl (R/S)-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetate

생성물 1

HCID 19817645N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1.0 g of ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)-acetate is treated with 10 ml of a 40% solution of methylamine in water. After stirring at room temperature for 1 hour, the mixture is evaporated. The residue is shaken five times with acetonitrile in order to remove the water, whereupon in each case it is again evaporated. The residue is treated with diethyl ether. By filtration there is isolated N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)-acetamide of melting point 129°-130.5°.

후처리

  1. customthe mixture is evaporated
  2. stirringThe residue is shaken five times with acetonitrile in order
  3. customto remove the water, whereupon in each case it
  4. customis again evaporated
  5. additionThe residue is treated with diethyl ether
  6. filtrationBy filtration

출처 및 근거

ORD 기록
ord-46cc396dd51c43869b186aa923631edc
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05034402

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