Ammonia → cis-(+-)-N-(2-(2,6-Dimethyl-1-piperidinyl)ethyl)-2-oxo-3-hydroxy-1-pyrrolidineacetamide

HRID 1087089

반응식

HRID 1087089 반응식
[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[N:3]1[CH2:9][CH2:10][NH:11][C:12](=[O:24])[CH2:13][N:14]1[CH2:18][CH2:17][CH:16]([O:19]C(=O)C)[C:15]1=[O:23].N>CO>[CH3:8][C@H:4]1[CH2:5][CH2:6][CH2:7][C@@H:2]([CH3:1])[N:3]1[CH2:9][CH2:10][NH:11][C:12](=[O:24])[CH2:13][N:14]1[CH2:18][CH2:17][CH:16]([OH:19])[C:15]1=[O:23]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 53715870(R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetamide

생성물 1

HCID 3069833cis-(+-)-N-(2-(2,6-Dimethyl-1-piperidinyl)ethyl)-2-oxo-3-hydroxy-1-pyrrolidineacetamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.3 g of (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetamide is stirred at room temperature for 2 hours in 30 ml of a saturated solution of ammonia in methanol. After evaporation of the methanol, the residue is treated three times with toluene and in each case again evaporated. After trituration in diethyl ether, there is obtained (R/S)-cis-N-[2(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide of melting point 129°-130°.

후처리

  1. customAfter evaporation of the methanol
  2. additionthe residue is treated three times with toluene
  3. customin each case again evaporated

출처 및 근거

ORD 기록
ord-f6a723b8bdd24b6c8d501c627b23f5d2
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05034402

연결된 노트

불러오는 중…