Ethylamine → 4-[3-(Ethylamino)-2-hydroxypropoxy]-benzonitrile
반응식
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1.[CH2:14]([NH2:16])[CH3:15]>C(#N)C>[CH2:14]([NH:16][CH2:3][CH:2]([OH:1])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1)[CH3:15]참가 물질
4
실험 절차
86.0 g of 4-(oxiranylmethoxy) benzonitrile was dissolved in 250 ml acetonitrile and mixed with 29.7 g ethylamine in an autoclave. The mixture was heated in a boiling water-bath over night, evaporated and the residue was dissolved in 2 M hydrochloric acid. This acid waterlayer was washed twice with ether, alkalized with 10 M sodium hydroxide and extracted with three portions of dichloromethane.
후처리
- temperatureThe mixture was heated in a boiling water-bath over night
- customevaporated
- dissolutionthe residue was dissolved in 2 M hydrochloric acid
- washThis acid waterlayer was washed twice with ether
- extractionextracted with three portions of dichloromethane
출처 및 근거
- ORD 기록
- ord-48aad3883f1f43f58357319d71e4c397
- 출처 데이터셋
- uspto-grants-1991_07
- 특허 번호
- US05034411
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