참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Trifluoroacetic anhydride | HCID 9845 | — |
| 반응물 | 3-Methyl-4-nitrobenzamide | HCID 595900 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Methyl-4-nitrobenzonitrile | HCID 2801434 | 93.1% |
반응 단계
To a stirred, 0° C. solution of 3-methyl-4-nitrobenzamide (30 g, 0.169 mol) in dichloromethane (900 mL) under nitrogen was added pyridine (29.5 g, 0.373 mol), then dropwise trifluoroacetic anhydride (42.7 g, 0.203 mol) in dichloromethane (90 mL). The reaction mixture was stirred at 0° C. for one hour and then 1N HCl was added. The organic phase was separated, dried (Na2SO4) and concentrated under reduced pressure to afford 25.5 g (93%) of the 3-methyl-4-nitrobenzonitrile as a light yellow solid; m.p. 69°-71° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05034410 |
|---|
| 출처 데이터셋 | uspto-grants-1991_07 |
|---|
| ORD ID | ord-b830a3aaa8c5415f9c4da848718c690f |
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| 출처 메모 | uspto-grants-1991_07 |
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