p-Chlorothiophenol → 3'-(4-Chlorophenylthio)-4'-nitroacetophenone

HRID 1087185노트

반응식

HRID 1087185 반응식
Cl[C:2]1[CH:3]=[C:4]([C:11](=[O:13])[CH3:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([SH:21])=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>C1(C)C=CC=CC=1.O>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21][C:2]2[CH:3]=[C:4]([C:11](=[O:13])[CH3:12])[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])=[CH:17][CH:16]=1

참가 물질

7

반응물 4

HCID 7815p-ChlorothiophenolHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 104427551-(3-Chloro-4-nitrophenyl)ethanone

생성물 1

HCID 103805263'-(4-Chlorophenylthio)-4'-nitroacetophenone수율 82.1%

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

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온도
70 °C

실험 절차

A mixture of 3'-chloro-4'-nitroacetophenone (1.5 g), 4-chlorothiophenol (1.63 g) and potassium carbonate (1.56 g) in toluene (15 ml) was stirred at 70° C. for 5 hours. Ethyl acetate and water were added, and the organic layer was separated, washed with water, dried and evaporated to dryness. The residue was washed with toluene to give yellow crystals of 3'-(4-chlorophenylthio)-4'-nitroacetophenone (1.9 g).

후처리

  1. customthe organic layer was separated
  2. washwashed with water
  3. customdried
  4. customevaporated to dryness
  5. washThe residue was washed with toluene

출처 및 근거

ORD 기록
ord-498c9783497a48b38347c9b20a02403c
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05034417

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