Ethyl Acetate → 2-Chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile

HRID 1087191노트

반응식

HRID 1087191 반응식
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7](Cl)=[CH:6][C:3]=1[C:4]#[N:5].[F:14][C:15]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:16]=1[S-:17].[K+].C(OCC)(=O)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([S:17][C:16]2[CH:18]=[CH:19][C:20]([F:22])=[CH:21][C:15]=2[F:14])=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 198177342,5-Dichloro-4-nitrobenzonitrileHCID 23700122Potassium 2,4-difluorothiophenoxide

생성물 1

HCID 198177012-Chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile수율 45.2%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 2,5-dichloro-4-nitrobenzonitrile (2.5 g) and potassium 2,4-difluorothiophenoxide (2.54 g) in toluene was stirred overnight. Ethyl acetate was added and the resulting mixture was washed with water, dried and evaporated. The residue was filtered and washed with toluene to give pale brown crystals of 2-chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile (1.7 g).

후처리

  1. washthe resulting mixture was washed with water
  2. customdried
  3. customevaporated
  4. filtrationThe residue was filtered
  5. washwashed with toluene

출처 및 근거

ORD 기록
ord-6d73aab75ba54c018334c300b3d59aa7
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05034417

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