Water → 1,2-Bis(3,4-dimethoxyphenyl)ethanone

HRID 1087287

반응식

HRID 1087287 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12]([OH:14])=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].O.[C:16]1([O:24][CH3:25])[C:17](=[CH:20][CH:21]=[CH:22][CH:23]=1)[O:18][CH3:19]>>[CH3:10][O:9][C:8]1[CH:7]=[CH:6][C:5]([CH2:11][C:12]([C:22]2[CH:21]=[CH:20][C:17]([O:18][CH3:19])=[C:16]([O:24][CH3:25])[CH:23]=2)=[O:14])=[CH:4][C:3]=1[O:2][CH3:1]

참가 물질

4

반응물 3

HCID 962WaterHCID 7043VeratroleHCID 7139(3,4-Dimethoxyphenyl)acetic acid

생성물 1

HCID 2311111,2-Bis(3,4-dimethoxyphenyl)ethanone수율 60%

실험 절차

A warm solution of 3,4-dimethoxyphenylacetic acid (10 g) in veratrole (15 ml) was added to 200 g of polyphosphoric acid (PPA). After 24 hrs. at room temperature the acid mixture was added to cold water (800 ml) and the product was collected and recrystallized from aqueous ethanol. The recrystallized intermediate (9.5 g, 60% yield) had a melting point of 104°-105°.

후처리

  1. customthe product was collected
  2. customrecrystallized from aqueous ethanol

출처 및 근거

ORD 기록
ord-39ca3b0eaeec40169d68941347309b1a
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05034544

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