Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 2-(4-Methylpiperazino)-3-phenylpropionic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | Ethyl 2-bromo-3-phenylpropanoate | HCID 4737529 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(4-Methylpiperazino)-3-phenylpropionic acid ethyl ester | HCID 15058496 | 14.3% |
반응 단계
EThyl 2-bromo-3-phenylpropionate (1.95 g) was treated with 3.05 g N-methylpiperazine as described in Example 95 to afford 0.30 g pure product after chromatography (9:1 CH2Cl2 :MeOH). NMR (300 MHz, CDCl3) delta 1.10 (d, J=7 Hz, 3H), 2.26 (s, 3H), 3.37 (m, 1H), 4.00 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05034376 |
| 출처 데이터셋 | uspto-grants-1991_07 |
| ORD ID | ord-199580f190c84b378ea700c2e98da722 |
| 출처 메모 | uspto-grants-1991_07 |