2-Amino-6-methylbenzothiazole → 2-methoxy-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide

HRID 1087471노트

반응식

HRID 1087471 반응식
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:12][O:13][CH2:14][C:15](Cl)=[O:16]>N1C=CC=CC=1>[CH3:12][O:13][CH2:14][C:15]([NH:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:5]=2[N:6]=1)=[O:16]

참가 물질

4

반응물 2

HCID 173352-Amino-6-methylbenzothiazoleHCID 96623Methoxyacetyl chloride

생성물 1

HCID 8365022-methoxy-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-Amino-6-methylbenzothiazole (4.9 g) is dissolved in pyridine (100 ml) and thereto is added dropwise methoxyacetyl chloride (3.0 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting oil is solidified with addition of water. The obtained solids are filtered off and washed with water, then with diethyl ether, dried and recrystallized from ethanol to give the title compound (4.1 g) having the following physical properties.

후처리

  1. distillationthe solvent is distilled off
  2. additionThe resulting oil is solidified with addition of water
  3. filtrationThe obtained solids are filtered off
  4. washwashed with water
  5. dry with materialwith diethyl ether, dried
  6. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-7d19eba1315d487793a9ea0570984494
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05036086

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