Amino-6-ethoxybenzothiazole, 2- → N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methoxyacetamide

HRID 1087472

반응식

HRID 1087472 반응식
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH2:12][CH3:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][O:15][CH2:16][C:17](Cl)=[O:18]>N1C=CC=CC=1>[CH2:12]([O:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:1][C:17](=[O:18])[CH2:16][O:15][CH3:14])[S:3][C:4]=2[CH:10]=1)[CH3:13]

참가 물질

4

반응물 2

HCID 7192Amino-6-ethoxybenzothiazole, 2-HCID 96623Methoxyacetyl chloride

생성물 1

HCID 652526N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methoxyacetamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-Amino-6-ethoxybenzothiazole (5.8 g) is dissolved in pyridine (100 ml) and thereto is added dropwise methoxyacetyl chloride (3.0 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting solids are washed with water, then with diethyl ether, dried and recrystallized from ethanol to give the title compound (5.1 g) having the following physical properties.

후처리

  1. distillationthe solvent is distilled off
  2. washThe resulting solids are washed with water
  3. dry with materialwith diethyl ether, dried
  4. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-f05414f5b307422c99104486583775b9
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05036086

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