Chlorosulfonic acid → 9-Dehydroandrostenedione

HRID 1087673

반응식

HRID 1087673 반응식
O[C@:2]12[CH2:19][CH2:18][C@@:16]3([CH3:17])[C@@H:12]([CH2:13][CH2:14][C:15]3=[O:20])[C@@H:11]1[CH2:10][CH2:9][C:8]1[C@:3]2([CH3:22])[CH2:4][CH2:5][C:6](=[O:21])[CH:7]=1.ClS(O)(=O)=O>>[CH3:17][C@:16]12[CH2:18][CH:19]=[C:2]3[C@@H:11]([CH2:10][CH2:9][C:8]4[C@:3]3([CH3:22])[CH2:4][CH2:5][C:6](=[O:21])[CH:7]=4)[C@@H:12]1[CH2:13][CH2:14][C:15]2=[O:20]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 104250179alpha-Hydroxyandrost-4-ene-3,17-dione

생성물 1

HCID 2395959-Dehydroandrostenedione

실험 절차

Following the procedure of Example 2 but making noncritical variations 9α-hydroxyandrostenedione (10.00 g.) is reacted with chlorosulfonic acid to give androsta-4,9(11)-diene-3,17-dione, 9.01 g. (90.1% weight yield, 95.7% chemical yield).

출처 및 근거

ORD 기록
ord-422490ac138a4a5b9529a1b8ab1ce25f
출처 데이터셋
uspto-grants-1990_10
특허 번호
USRE033364

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