Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphoric Acid → 9-Dehydroandrostenedione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphoric Acid | HCID 1004 | — |
| 반응물 | 9alpha-Hydroxyandrost-4-ene-3,17-dione | HCID 10425017 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 9-Dehydroandrostenedione | HCID 239595 | — |
반응 단계
9α-Hydroxyandrostenedione (280 mg.; 302 mg. of 92.7% purity) is added to phosphoric acid (85%, 5 ml.) and stirred at 35°-48° for 7.5 hours. Water (10 ml.) is then added, the mixture stirred and filtered. The solids are air-dried at 25° for 10 hours to give androsta-4,9(11)-diene-3,17-dione, 254 mg. (90.7% weight yield, 96.2% chemical yield); m.p. 197°-201°. GC (Example 1) shows an androsta-4,9(11)-diene-3,17-dione/androsta-4,8-diene-3,17-dione ratio greater than 99 to 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE033364 |
| 출처 데이터셋 | uspto-grants-1990_10 |
| ORD ID | ord-0add41fbe6454ad9b178403b89f5016f |
| 출처 메모 | uspto-grants-1990_10 |