Water → 2-Chloro-1-(2,4-difluorophenyl)-2-fluoroethan-1-one

HRID 1087770노트

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HRID 1087770 반응식
[F:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4].O.S(Cl)([Cl:17])(=O)=O>>[F:1][CH:2]([Cl:17])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4]

참가 물질

4

반응물 3

HCID 962WaterHCID 24648Sulfuryl chlorideHCID 22163867Ethanone, 1-(2,4-difluorophenyl)-2-fluoro- (9CI)

생성물 1

HCID 221638632-Chloro-1-(2,4-difluorophenyl)-2-fluoroethan-1-one

실험 절차

A solution of 2,2',4'-trifluoroacetophenone (1.60 g; 9.2 mM) in sulphuryl chloride (4 ml) was heated at 75° for 18 hours. The mixture was then cooled and iced-water (40 ml) was added. The product was extracted into ether (80 ml), which was washed with water and aqueous sodium bicarbonate solution, and then dried over magnesium sulphate. Evaporation yielded the desired product as a colourless, intensely lachrymatory liquid (2.0 g; 100%).

후처리

  1. temperatureThe mixture was then cooled
  2. extractionThe product was extracted into ether (80 ml), which
  3. washwas washed with water and aqueous sodium bicarbonate solution
  4. dry with materialdried over magnesium sulphate
  5. customEvaporation

출처 및 근거

ORD 기록
ord-0dff33e52fe64197946070a2cd32454e
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04960782

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