Benzene → 2-Bromo-6-(3-chloroprop-1-en-2-yl)pyridine

HRID 1087939

반응식

HRID 1087939 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([CH3:10])=[CH2:9])[N:3]=1.[Cl:11]N1C(=O)CCC1=O.C1C=CC=CC=1>CCCCCC>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([CH2:10][Cl:11])=[CH2:9])[N:3]=1

참가 물질

5

반응물 3

HCID 241BenzeneHCID 31398ChlorosuccinimideHCID 221642832-Bromo-6-(prop-1-en-2-yl)pyridine

생성물 1

HCID 150087152-Bromo-6-(3-chloroprop-1-en-2-yl)pyridine수율 35.5%

시약·촉매·용매 1

HCID 8058Hexane용매

반응 조건

온도
80 °C

실험 절차

A mixture of 3.60 g of 2-bromo-6-isopropenylpyridine, 2.91 g of N-chlorosuccinimide and 8 ml of benzene was stirred at 80° C. for 5 hours. After the reaction mixture was cooled to room temperature, n-hexane was added thereto to remove the insoluble matter through filtration. After distilling off the solvent, the residue was purified by silica gel column chromatography (eluted with n-hexane then n-hexane - ethyl acetate 20:1) to obtain 1.50 g of the objective compound.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. customto remove the insoluble matter
  3. filtrationthrough filtration
  4. distillationAfter distilling off the solvent
  5. customthe residue was purified by silica gel column chromatography (
  6. washeluted with n-hexane

출처 및 근거

ORD 기록
ord-b7d5909c2c024bb2ae7265eead7b8df9
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04960897

연결된 노트

불러오는 중…