Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1088295생성일: 2026년 10월 27일
N-(1,1-Dimethylethyl)-1,3-propanediamine → N-[3-[(1,1-Dimethylethyl)amino]propyl]-4,5-diphenyl-1H-imidazole-1-acetamide
https://huagongshe.com/reaction/1088295
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N-(1,1-Dimethylethyl)-1,3-propanediamine | HCID 40274 | — |
| 반응물 | 3-(tert-BUTYLAMINO)PROPIONITRILE | HCID 2757246 | — |
| 반응물 | Ethyl 4,5-diphenyl-1H-imidazole-1-acetate | HCID 14820171 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-[3-[(1,1-Dimethylethyl)amino]propyl]-4,5-diphenyl-1H-imidazole-1-acetamide | HCID 14820174 | 50.1% |
반응 단계
A mixture of 7.0 g (23 mmol) of ethyl 4,5-diphenyl-1H-imidazole-1-acetate of example 1 and 4.5 g (34.6 mmol) of 3-(t-butylamino)propylamine, conveniently made by LAH reduction of 3-(t-butylamino)propionitrile in THF, was heated at 100° C. for 8 hr. The residue was distributed between water and methylene chloride, and the methylene chloride layer was dried over MgSO4 and stripped. The residue was recrystallized from ether and then cyclohexane to yield 4.5 g of product, mp 94°-96° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04962120 |
|---|
| 출처 데이터셋 | uspto-grants-1990_10 |
|---|
| ORD ID | ord-c994c8e965704442a0afefbd84abbe5a |
|---|
| 출처 메모 | uspto-grants-1990_10 |
|---|
