3-Pyridineacrylic acid ethyl ester → 2-Propen-1-ol, 3-(3-pyridinyl)-

HRID 1088576

반응식

HRID 1088576 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9](OCC)=[O:10])[CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][CH2:9][OH:10])[CH:2]=1

참가 물질

3

반응물 2

HCID 5833373-Pyridineacrylic acid ethyl esterHCID 21226445Aluminium lithium hydride

생성물 1

HCID 35635042-Propen-1-ol, 3-(3-pyridinyl)-

실험 절차

Ethyl 3-(3-pyridyl)acrylate was reduced using lithium aluminum hydride to give 3-(3-pyridyl)-2-propen-1-ol. In 30 ml of acetone 710 mg of 3-(3-pyridyl)-2-propen-1-ol and 980 mg of methyl p-toluenesulfonate were heated under reflux for 22 hours. The reaction mixture was subjected by decantation to remove the solvent and then washed with acetone and ether. The residue was dried under reduced pressure to give 1.3 g of the desired compound as an orange-colored oil.

출처 및 근거

ORD 기록
ord-c33a204a8bac44d0aac96c9a5bb92baf
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04962096

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