N-morpholinocarbonyl-L-phenylalanine benzyl ester → CP 84364

HRID 1088613

반응식

HRID 1088613 반응식
C([O:8][C:9](=[O:27])[C@H:10]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH:11][C:12]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:13])C1C=CC=CC=1.[H][H]>CO.[Pd]>[O:17]1[CH2:18][CH2:19][N:14]([C:12]([NH:11][C@H:10]([C:9]([OH:27])=[O:8])[CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:13])[CH2:15][CH2:16]1

참가 물질

5

반응물 2

HCID 14478228N-morpholinocarbonyl-L-phenylalanine benzyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 664657CP 84364수율 94.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of N-morpholinocarbonyl-L-phenylalanine benzyl ester (1.43 g) in methanol (20 ml) was hydrogenated over 10% palladium on carbon (150 mg) at 3 atmospheric pressure of hydrogen for 1 hour. The solution was filtered and concentrated in vacuo to give N-morpholinocarbonyl-L-phenylalanine (1.02 g) as an amorphous powder.

후처리

  1. filtrationThe solution was filtered
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-14ba90aef92248cb8d0b54e1cd080a1a
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04963530

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