Thionyl Chloride → 2-(Chloromethyl)-3,4-dimethoxypyridine

HRID 1089117노트

반응식

HRID 1089117 반응식
[CH3:1][O:2][C:3]1[C:4]([CH2:11]O)=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH3:10].O=S(Cl)[Cl:15].C([O-])(O)=O.[Na+]>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:4]([CH2:11][Cl:15])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 107258093,4-Dimethoxy-2-pyridinemethanol

생성물 1

HCID 50797222-(Chloromethyl)-3,4-dimethoxypyridine수율 162.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

3,4-Dimethoxy-2-hydroxymethylpyridine (0.34 g, 0.002 mol) was dissolved in CH2Cl2 (8 ml). SOCl2 (0.27 g, 0.00227 mol) in CH2Cl2 (2 ml) was added under stirring at room temperature. After 10 min the mixture was neutralized with NaHCO3 (5 ml). The phases were separated, the CH2Cl2 phase was washed with NaCl-solution, dried over Na2SO4 and evaporated giving the desired product (0.61 g, 88%).

후처리

  1. customThe phases were separated
  2. washthe CH2Cl2 phase was washed with NaCl-solution
  3. dry with materialdried over Na2SO4
  4. customevaporated

출처 및 근거

ORD 기록
ord-58a80bb84e824ffcac598bac364ec0bd
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04965269

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