alpha-(1-Methylpyrazol-5-yl)-2,3-dichloro-4,5-dimethoxybenzylalcohol → (1-Methylpyrazol-5-yl)-(2,3-dichloro-4,5-dimethoxyphenyl)-methanone

HRID 1089168

반응식

HRID 1089168 반응식
[CH3:1][N:2]1[C:6]([CH:7]([OH:20])[C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([Cl:18])[C:9]=2[Cl:19])=[CH:5][CH:4]=[N:3]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][N:2]1[C:6]([C:7]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([Cl:18])[C:9]=2[Cl:19])=[O:20])=[CH:5][CH:4]=[N:3]1

참가 물질

4

반응물 1

HCID 14748635alpha-(1-Methylpyrazol-5-yl)-2,3-dichloro-4,5-dimethoxybenzylalcohol

생성물 1

HCID 14748594(1-Methylpyrazol-5-yl)-(2,3-dichloro-4,5-dimethoxyphenyl)-methanone수율 90.3%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

20 g of manganese dioxide are added to a solution of 7.08 g of α-(1-methylpyrazol-5-yl)-2,3-dichloro-4,5dimethoxybenzylalcohol in methylene chloride and the mixture is stirred at room temperature for 3 days. The reaction mixture is filtered and washed with chloroform. The filtrate and the washings are combined and evaporated to remove solvent. The residue is crystallized from n-hexane to give 6.35 g of (1-methylpyrazol-5-yl)-(2,3-dichloro-4,5-dimethoxyphenyl)-methanone.

후처리

  1. filtrationThe reaction mixture is filtered
  2. washwashed with chloroform
  3. customevaporated
  4. customto remove solvent
  5. customThe residue is crystallized from n-hexane

출처 및 근거

ORD 기록
ord-e1a3d1a09cd847839682edd745e18b22
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04965282

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