Triethylamine → 1-(2-Acetylaminoethyl)-2,5-dimethyl-3-methylsulphinylpyrrole

HRID 1089436노트

반응식

HRID 1089436 반응식
[CH3:1][S:2](Cl)=[O:3].[C:5]([NH:8][CH2:9][CH2:10][N:11]1[C:15]([CH3:16])=[CH:14][CH:13]=[C:12]1[CH3:17])(=[O:7])[CH3:6].C(N(CC)CC)C.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[C:5]([NH:8][CH2:9][CH2:10][N:11]1[C:12]([CH3:17])=[CH:13][C:14]([S:2]([CH3:1])=[O:3])=[C:15]1[CH3:16])(=[O:7])[CH3:6]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 548463Methanesulfinyl chlorideHCID 13770049N-(2-(2,5-Dimethyl-1H-pyrrol-1-yl)ethyl)acetamide

생성물 1

HCID 145367551-(2-Acetylaminoethyl)-2,5-dimethyl-3-methylsulphinylpyrrole

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

19.7 g (0.2 mol) of methylsulphinyl chloride are dissolved in 500 ml of methylene chloride. 36.0 g (0.2 mol) of 1-(2-acetylaminoethyl)-2,5-dimethylpyrrole and 27.6 ml (0.2 mol) of triethylamine in 500 ml of methylene chloride are added dropwise at 0° C. and the mixture is stirred at 0° C. for 45 minutes and poured onto aqueous sodium bicarbonate solution. The organic phase is separated off and discarded. The aqueous phase is concentrated and the residue is boiled up with isopropanol and, after the mixture has been concentrated, the product is chromatographed.

후처리

  1. customThe organic phase is separated off
  2. concentrationThe aqueous phase is concentrated
  3. concentrationafter the mixture has been concentrated
  4. customthe product is chromatographed

출처 및 근거

ORD 기록
ord-4f539bc04d6443cdaa8a93904c4f8384
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04966901

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