참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hexachloroethane | HCID 6214 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Tetrachloroethylene | HCID 31373 | — |
| 반응물 | Montelukast Impurity 38 | HCID 12241574 | — |
| 촉매 | Dodecyltrimethylammonium chloride | HCID 8152 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 20541564 | HCID 20541564 | 85.2% |
반응 단계
α,α,α'-Trichloro-m-xylene (22.5 grams, 93.2% a.i., 0.1 moles) was dissolved in 18 mls. of tetrachloroethylene. Hexachloroethane (59.2 grams, 0.25 moles), potassium hydroxide (12.8 grams, 87.7%, 0.2 moles), water (2.13 grams), and dodecyltrimethylammonium chloride (0.255 grams, 0.001 moles) were added. The mixture was heated at 75° C. for 2.5 hours with good stirring. The reaction was quenched with 30 mls. of water and 18 mls tetrachloroethylene. The organic phase was separated and washed with water. The excess solvent and hexachloroethane were distilled off to give an 85.2% yield of α,α,α,α'-tetrachloroxylene with a purity of 84%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04966988 |
|---|
| 출처 데이터셋 | uspto-grants-1990_10 |
|---|
| ORD ID | ord-6580e92b726c4f0bb5b585fe2ca38b3a |
|---|
| 출처 메모 | uspto-grants-1990_10 |
|---|
